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In a randomised controlled trial with overweight/obese people, once-weekly survodutide induced dose-dependent mean body-weight changes up to 14.9% for those assigned to the maximum dose of 4.8 mg, compared to 2.8% with placebo
Access, cost and appropriate use will determine impact
However, very high doses taken for extended periods may increase the risk of mild gastrointestinal symptoms
Approximately 6% of people under age 60 and 20% of people over age 60 are vitamin B12 deficient
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